Analysis of TCGA-based dataset by Gitools 2.3.1 revealed the following dominant APP signature: BL-BC subtype representing TNBC highly expressed SAA1, SAA2, SAA4 and TF. Both BL and HER2 subtypes highly expressed ORM1 and CP (Figure 1A and 1B), while LA subtype highly expressed SERPINA1 and SERPINA2 (Figure 1A and 1B). The gene discussed is ORM1; the disease is breast cancer.