While previous studies have examined the in vitro efficacy of BCL-2/BCL-xL inhibitors in HNSCC, both as single agents and in combination with chemotherapy, our study presents the examination of ABT-263 (navitoclax) alone and in combination with cisplatin in the largest number of HNSCC cell lines reported to date. The gene discussed is BCL2; the disease is head and neck squamous cell carcinoma.