Based on recent literature [72], we hypothesized that the SKI-II driven increase in C16 Cer levels (Supplementary Figure 9B) and decrease in S1P/C16 Cer (Figure 7) would enhance cancer subclone sensitivity to drugs, like BH3I-1, that directly induce mitochondrial outer membrane permeabilization via Bax/Bak. The gene discussed is BAK1; the disease is cancer.