These findings indicate that 5-Lox activity may contribute to the survival and apoptosis-resistance of prostate cancer stem cells by metabolic conversion of arachidonic acid (an omega-6 polyunsaturated fatty acid, plentiful in our diets) and activation of PKCε, a transforming oncogene, and suggest that targeting 5-Lox with suitable agents may yield clues about effective, long-lasting therapy of prostate cancer and prevention of prostate cancer recurrence. This evidence concerns the gene PRKCE and Familial prostate cancer.