This report documents that inhibition of 5-Lox, triggers rapid and wide-spread apoptosis in prostate cancer stem cells via activation of c-Jun N-terminal Kinase, and that this process is associated with down-regulation of PKCε, but not Akt or ERKs as we observed in regular prostate cancer cells [23–26, 37]. The gene discussed is JUN; the disease is Familial prostate cancer.