Although this modulatory effect is predictable since several reports have documented that naringenin might regulate cGMP or PKG signaling in the vascular system [62] and nervous system [63, 64], to the best of our knowledge, the present study is still the first one to elucidate the relationship between naringenin and cGMP-PKGIα signaling during ischemic heart disease. The gene discussed is PRKG1; the disease is coronary artery disorder.