For the LPS-induced ARDS model, in addition to increasing susceptibility and severity in Nrf2-deficient mice, it is also intriguing to find that Nrf2 may provide protective effects on LPS-induced ARDS via its promotion of M2 polarization in macrophages in a recent study adopting the Nrf2 activator tert-butylhydroquinone (tBHQ) and Nrf2 siRNA [96]. Here, NFE2L2 is linked to acute respiratory distress syndrome.