Intriguingly, one of its major derivatives, bis[2-hydroxybenzylidene]acetone (BHBA), also significantly upregulates Nrf2 signaling, counteracts sodium arsenite- [As(III)-] induced cytotoxicity in a lung epithelial cell line and inhibits tumor formation in a vinyl carbamate-induced lung adenocarcinoma model of A/J mice [176]. Here, NFE2L2 is linked to lung adenocarcinoma.