NFE2L2 and pulmonary fibrosis: Apart from the above compounds, the antifibrotic effects of berberine and epigallocatechin-3-gallate (EGCG) on bleomycin-induced pulmonary fibrosis in a murine model may also be at least partly mediated by the activation of Nrf2 signaling, accompanied by the inhibition of inflammation and other biological events [149, 155].