NFE2L2 and acute respiratory distress syndrome: A previous study showed that Nrf2 may act as a candidate gene of ARDS susceptibility for humans, as over 500 single-nucleotide polymorphisms (SNPs) of Nrf2 have been identified to date, and the risk of ARDS after severe trauma has increased in people with a functional NRF2 SNP in European and African American individuals [90].