In the hyperoxia-induced rodent model of ARDS, Nrf2 is supposed to be a susceptibility gene because functional SNPs have been found in hyperoxia-susceptible C57BL/6J (B6) and hyperoxia-resistant C3H/HeJ (C3) mice, and the B6C3F2 progeny is reported to have a hyperoxia-susceptibility promoter SNP [91, 92]. This evidence concerns the gene NFE2L2 and acute respiratory distress syndrome.