The well-known antioxidant vitamin E (α-tocopherol) is also reported to protect against IgE-induced asthma by reversing the impairment of Nrf2 activity in alveolar macrophages in vivo and alleviating asthma exacerbation stimulated by ozone in the OVA-induced murine model via the Nrf2 pathway, although its effect is absent on OVA-induced asthma symptoms [141, 142]. Here, IGHE is linked to asthma.