Notably, unlike the chronic rejection observed in the WT group, BALB/c heart grafts survived long-term in the SAP−/− recipients (Figure 5C), without evidence of endothelial complement deposition (Figure 2A) and with the development of only minimal allograft vasculopathy, and parenchymal injury (Figure 5D). The gene discussed is SH2D1A; the disease is vascular disorder.