We and others have shown the susceptibility of type I interferon receptor (IFNAR)-deficient A129 mice, as well as type I and II interferon receptor (IFNAR/IFNGR)-deficient AG129 and AG6 mice, to ZIKV, and identified candidate vaccines and therapeutic agents that protect against ZIKV infection in these mouse models (Aliota et al., 2016; Cui et al., 2017; Du et al., 2017; Wu et al., 2017; Sumathy et al., 2017; Yu et al., 2017; Espinosa et al., 2018; Tai et al., 2018; Jiang and Du, 2019). Here, IFNAR1 is linked to Zika virus infectious disease.