IFNG and inflammatory bowel disease: The dysregulation of TJs leads to altered barrier function resulting in changes in levels of inflammatory cytokines such as IFN-α, IFN-gamma, IL-6 and IL-1β as seen in inflammation associated diseases such as IBD, multiple sclerosis and cancer (Harhaj and Antonetti, 2004; Turner, 2006; Cereijido et al., 2007).