The data confirms that sham-operated FHH displayed cardiac hypertrophy as compared with FHL rats and the induction of ACF caused marked cardiac hypertrophy, to the same extent in FHL and FHH, as soon as 6 weeks after ACF creation, The treatment with sEH inhibitor did not alter the degree of cardiac hypertrophy, similarly in sham-operated FHH or ACF FHL rats and ACF FHH rats. Here, EPHX2 is linked to cardiac hypertrophy.