Moreover, in the spontaneously hypertensive heart failure rat, an inbred, genetically homogenous model that mirrors human hypertension-associated heart failure (McCune et al., 1990), an alteration of the gene encoding sEH (Ephx2) facilitated CHF progression and was identified as a heart failure susceptibility gene (Monti et al., 2008). Here, EPHX2 is linked to congestive heart failure.