For example, in CML some autophagy-related genes (such as ATG4, ATG5, or BECLIN 1 [37–39]) are upregulated and the silencing of both ATG7 or ATG4B affects cell survival; so, the levels of autophagy in CML seems to be closer to solid tumor CSCs. Here, ATG5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.