EGFR and breast cancer: Different signaling pathways have been identified: in MMTV-PyMT transgenic mice (a mouse model of breast CSCs), Yeo et al. [42] demonstrated that autophagy acts through EGFR/Stat3 and Tgfβ/Smad signaling in two distinct breast cancer stem-like cells (ALDH+ and CD29hiCD61+ , respectively, see Fig. 2b).