Given that, in F1 DOSS treatment mice, normalized adiponectin levels were more consistently lower compared to leptin level increases (whose consistency were dependent on a two-gram adipose tissue threshold; Fig. 4B), adiponectin may serve as a better marker than leptin for predicting developmental DOSS exposure and for predicting which individuals exposed to DOSS are likely to develop metabolic syndrome. Here, ADIPOQ is linked to metabolic syndrome.