Based on the above findings, the panel of the T2D-specific transcript variants finally included the: CAPN10 tv3, CDK5 tv1, CDK5 tv2, CDKN2A tv3, CDKN2A tv4, IGF2BP2 tv7, KCNQ1 tv1, THADA tv5 and TSPAN8. Among them, binomial multivariate analysis corrected for age and sex revealed that CAPN10 tv3 can predict T2D among participants of the current study (p = 0.022, OR = 0.726). The gene discussed is CDK5; the disease is type 2 diabetes mellitus.