Based on public available data of the GTEx portal19, the CAPN10, CDK5, CDKN2A, IGF2BP2, KCNQ1, THADA and TSPAN8 genes, as well as their transcript variants CDK5 tv1, CDK5 tv2, IGF2BP2 tv7, KCNQ1 tv1 and THADA tv5, are expressed in a series of human tissues including blood and T2D-target tissues (adipose tissue, liver, skeletal muscle, pancreas) (Fig. 3). The gene discussed is CAPN10; the disease is type 2 diabetes mellitus.