In CRC, Li et al. also found that FOXM1 binds specifically to two regions of the PLAUR (urokinase-type plasminogen activator receptor) gene promoter, and it gene product functions to degrade the extracellular matrix during cell migration and proliferation, supporting the view that FOXM1 is a master regulator of tumorigenesis38. This evidence concerns the gene PLAUR and colorectal carcinoma.