BRCA2 and colorectal cancer: In colorectal cancer, the genes that were significantly enriched for copy number gain in TCGA versus GENIE were BRCA2 (60% versus 23%, p < 0.0001), BRAF (48% versus 11%, p < 0.0001) and KRAS (22% versus 3%, p < 0.0001) (Fig. 5(b)).