TFRC and hepatocellular carcinoma: We demonstrate that increased miR-148a levels downregulate the expression of endogenous TFR1 mRNA and protein in HCC cell lines (HepG2 and Huh7) (Fig. 5B,D) and that suppression of TFR1 expression directly or mediated by miR-148a overexpression decreases HCC cell proliferation (Figs 6,7).