TFRC and hepatocellular carcinoma: Moreover, knockdown of TFR1 by two different siRNAs in HCC cells significantly decreased cell proliferation; HepG2 cells siRNA 1 (F(4,64) = 7.011; P < 0.0001) siRNA 2 (F(4,64) = 4.346; P = 0.0036) (Fig. 6C) and Huh7 cells siRNA 1 (F(4,64) = 4.928; P = 0.0016) siRNA 2 (F(4,64) = 2.727; P = 0.0368) (Fig. 6D).