However, Nut treatment did not induce nuclear deformation in WI-26 (SV40 Large T antigen-expressed lung fibroblasts; Supplementary Fig. 9A and 9B) or Capan-1 (p53-mutated pancreatic cancer cell line; Supplementary Fig. 9C and 9D). Here, NUTM1 is linked to familial pancreatic carcinoma.