TRIP11 and odontochondrodysplasia 1: Our clinical observations add 2 important aspects to the description of ODCD (10–12): first, there is considerable clinical variability in TRIP11-related disorders, with early lethality and milder postnatal phenotypes occurring within the same family, and second, there are extraskeletal disease manifestations in ODCD that implicate GMAP-210 in human renal and cerebral development (15).