COL1A1 and odontochondrodysplasia 1: This is also the result of reduced nonglycanated core protein at 40 kDa in ACG1A and severe ODCD, matching the findings for secreted pro-COL1A1 (Figure 8D) and supporting the notion that impaired protein trafficking of specific substrates (6) and their altered posttranslational modification may contribute independently to the pathogenesis and severity of TRIP11-related disorders.