In another study, older people with depression had a lower serum folate level (21.5 nmol/L) compared to those without depression (24.0 nmol/L) and there was a linear relationship between decreased folate concentration and increased risk of developing depressive symptoms, independent of other risk factors including demographic, chronic diseases, nutritional risk, albumin, anemia and vitamin supplements such as vitamin B12, homocysteine etc. In addition, vitamin B12 deficiency was significantly related to depressive symptoms34. This evidence concerns the gene ALB and anemia (phenotype).