In follow-up studies with a high-fat, high-sucrose diet, cod protein feeding, as compared with soya protein and casein feeding, prevented rats from developing skeletal muscle insulin resistance(181) by normalising skeletal muscle insulin-stimulated phosphoinositide 3-kinase activity and downstream protein kinase B (Akt) signalling and by improving translocation of GLUT4 to cell-surface membranes(182). The gene discussed is AKT1; the disease is Insulin resistance.