KRAS and Carcinoma, Lewis Lung: In vitro treatment of syngeneic murine lung cancer line Lewis Lung Carcinoma (LLC), KP9–1, a cell line derived from concurrent Kras and p53 (KrasG12D, p53−/−) mutant mouse lung tumor, and human lung adenocarcinoma cancer cell lines A549 and H460 revealed no cytotoxic activity (Additional file 2: Figure S7D and data not shown).