MAPK4 and Miyoshi myopathy: It was demonstrated that the level of MAPK4 in MM cell lines was markedly increased, The expression of MAPK4 in MM.1S and NCI-H929 cells treated with circ_0000190 was dramatically decreased and the over-expression ofcirc_0000190 significantly enhanced the level of MAPK4,revealing the regulatory role of circ_0000190 on MAPK4 expression.