Over-expression ofcirc_0000190 significantly decreased cell viability and proliferation, inhibited cell cycle and blocks cell cycle at G1 stage with down-regulation of CDK6, CDK4, Cyclin D1 and Cyclin E, while up-regulation p21Cip1.These results indicated that circ_0000190 may serve a cancer-suppressive role in MM progression. This evidence concerns the gene CDK4 and Miyoshi myopathy.