Over-expression ofcirc_0000190 significantly decreased cell viability and proliferation, inhibited cell cycle and blocks cell cycle at G1 stage with down-regulation of CDK6, CDK4, Cyclin D1 and Cyclin E, while up-regulation p21Cip1.These results indicated that circ_0000190 may serve a cancer-suppressive role in MM progression. The gene discussed is CDK4; the disease is cancer.