We further investigated whether SNHG1 can control the expression of FOXP2 and KDM5B by regulating the expression of miR-154-5p and miR-376b-3p to understand their potential mechanism in regulating biological behaviors of glioma cells and lay down a new fundation for targeted therapy aiming to cure human glioma. The gene discussed is SNHG1; the disease is glioma.