In the current study of glioma, miR-154-5p combined with PIWIL1 3 ‘UTR inhibits malignant progression of glioblastoma, the overexpression of miR-154-5p can inhibit proliferation and metastasis of malignant glioma cells and induce apoptosis; miR-154 can also be used as a potential biomarker for clinical prognosis in patients with glioma [13, 42]. Here, PIWIL1 is linked to malignant glioma.