TRIM14 and central nervous system cancer: As shown in Additional file 2: Figure S2A and B(***p < 0.001, n = 3), although downregulating TRIM14 by two shTRIM14 showed no statistical influence on cell proliferation in the first three days, but significantly reduced cell proliferation of LN229 and U251 cell after 5 days, indicating that TRIM14 also had potential abilities to promote the glioma cell growth(***p < 0.001, n = 3, Additional file 2: Figure S2B).