Biologically, YBCs in our study showed aggressive phenotypes with relatively high proportion of large tumor size, lymph node involvement, advanced and metastatic diseases, high histology grade, angiolymphatic invasion, Her-2 positivity, TNBC subtype, as well as frequent progression and relapse during follow-up (Table 2) in accordance with previous studies [6, 15–17]. The gene discussed is ERBB2; the disease is neoplasm.