The pooled HRs of cumulative meta analysis ranged from 1.48(95%CI 1.1–2.0) to 2.14 (95%CI 1.64–2.79) for OS in univariate analysis since 1999, demonstrating that performance of Ki-67 expression for OS in CRC patients was stable and reliable. This evidence concerns the gene MKI67 and colorectal carcinoma.