Interestingly enough, Nash reported that patients with KRAS mutant tumors that expressed high levels of Ki-67 had significantly worse DFS than patients with KRAS wild-type tumors that expressed low level of Ki-67, indicating that combined application of these predictive genes might provide more valuable prognostic information and further improve the clinical prediction of prognosis for CRC patients. The gene discussed is KRAS; the disease is colorectal carcinoma.