NUMB and cancer: Given that RTKs constitute a major portion of the NUMB-PTB interactome (Wei et al., 2018) and are involved in the pathogenesis of numerous types of cancer, the NUMB isoform-specific pro- or anti-tumorigenesis role (Westhoff et al., 2009; Misquitta-Ali et al., 2011; Bechara et al., 2013) may be exploited for prognostic or therapeutic applications.