We hypothesized that elevated plasma GLP-1 levels triggered by glucose ingestion were responsible for the high insulin secretion rates and subsequent hypoglycemia observed in our lean human cohort after gastrectomy (Roberts et al., 2018b), as reported previously in bariatric patients (Craig et al., 2017, Jørgensen et al., 2013, Salehi et al., 2014). This evidence concerns the gene INS and Hypoglycemia.