PLAT and intracranial hemorrhage: In the OPTALYSE PE study, four patients (4%) suffered 5 major bleeding events, included one intracranial hemorrhage attributed to CDT; this patient had been randomized to receive 12–24 mg t-PA over 6 h, a higher dose over a shorter duration compared to the ULTIMA (10–20 mg t-PA over 15 h) and SEATTLE II (24 mg t-PA over 12–24 h) trials [3].