This statistical observation should be interpreted with caution, as prior studies have demonstrated increased bleeding with more prolonged thrombolysis [25]; in addition, two major hemorrhagic events, including one intracranial hemorrhage, occurred in 18 patients assigned to the highest dose arm (12–24 mg t-PA over 6 h) in the OPTALYSE PE study[3]. Here, PLAT is linked to intracranial hemorrhage.