To evaluate our hypothesis that immune-mediated clearance of PDAC after radiation would be enhanced following CAF depletion, we adoptively transferred 1x106 CD8+ T cells from either WT or FAP KO LM-βgal vaccinated animals, with approximately 10–15% of cells testing for βgal reactivity, into tumor-bearing WT or FAP KO animals on day 4, and tumors were harvested on day 14 and evaluated for CAF depletion. The gene discussed is FAP; the disease is neoplasm.