LDLR and Sepsis: Select studies involved murine models.[9] Walley, et al. demonstrated that LDL-R and PCSK9 are critical regulators of endotoxin clearance in sepsis.[8, 10, 11] However, Berger, et al. found that PCSK9 LOF mutations did not affect lipopolysaccharide-induced mortality and failed to find a role for LDL-R in the process at all.