LDLR and Sepsis: For example, PCSK9’s LDL-R degrading function may decrease hepatocyte endotoxin clearance.[8] A murine study found that PCSK9 inhibition reduced sepsis mortality.[9] PCSK9 levels have been reported to be increased in septic patients, leading to decreased endotoxin clearance and increased rates of organ failure.[10] Walley et al. found better outcomes of septic shock in patients with lower serum PCSK9 protein levels.[11]