We report on analysis of GABAAR and MYC expression in 763 primary medulloblastoma patient tumors, characterization of GABAAR in a patient-derived cell line, identification of chemical features critical to α5-GABAAR preferring benzodiazepine potency, and examination of how such benzodiazepines may impair group 3 cell viability. This evidence concerns the gene MYC and medulloblastoma.