Bcl‐2 protein inhibits the release of cytochrome c from mitochondria to the cytosol and regulates the activation of caspases for apoptosis induction.59 In addition, many reports showed that the inhibition of Bcl‐2 expression by chemotherapeutic agents increased the sensitivity of cancer cells to TRAIL.60, 61. This evidence concerns the gene TNFSF10 and cancer.