TNFSF10 and cancer: Caspase‐8 is an essential mediator for the initiation of DR‐induced apoptosis41, 42 and frequently absent in cancers such as neuroblastoma,41, 43, 44 medulloblastoma,43, 45 small cell lung cancer46 and melanoma.41 The loss of caspase‐8 expression correlates with low sensitivity to TRAIL cytotoxicity.