TNFSF10 and cancer: Tumour necrosis factor–related apoptosis‐inducing ligandis widely used for cancer therapy and effectively kills several transformed cells but not normal cells.12, 31 Although TRAIL may serve as a promising cancer therapeutic agent, many cancer cells exhibit partial or complete resistance to TRAIL.12, 31 This resistance may be attributed to the deregulated expression of the TRAIL receptors or intracellular components which act downstream of the receptors.