BCL2 and neoplasm: Collectively, these oncogenic or tumour suppressor miRNAs contribute to OS drug resistance by regulating expression of apoptosis‐related genes to avoid cell apoptosis, such as CCND1 and BCL2. Considering that BCL2 is a classic anti‐apoptotic protein that promotes cell survival by inhibiting activation of a caspase cascade, and is associated with several miRNAs in OS chemoresistance, it's presumable that BCL2 might be critical for the reversal of MDR in OS.