Thus, our study showed novelty in terms of the HSR as follows: (a) the influence of obesity/T2DM in eHSP70 plasma concentration and H-index (eHSP72/iHSP70 ratio) after exercise was dependent on exercise intensity, (b) acute environmental air pollution exposure modified the effects of exercise in obesity, and (c) these effects on HSP70 were not accompanied by altered oxidative stress biomarkers or by hematological changes. This evidence concerns the gene HSPA1A and type 2 diabetes mellitus.