SLC16A1 and pulmonary arterial hypertension: Further, DCA induced apoptosis in the MCT-PAH pulmonary arteries (PAs) and suppressed cell growth rates measured by bromodeoxyuridine (BrdU) uptake in the medial layer of remodeled MCT-PAH PAs with little impact on normal pulmonary vascular cells in rats and humans, making it a promising small molecule for targeted restoration of normal metabolic dysfunctions in PAH ECs (Stacpoole et al., 2003; McMurtry, 2004; Ryan and Archer, 2015).