The factors significantly associated with RFS of CCRCC patients were sex (P = 0.033), age (P = 0.022), tumor size (P < 0.001), tumor stage (P < 0.001), lymph node metastasis (P = 0.010), nuclear grade (P = 0.006), Nu-FAM83H (P < 0.001), Cy-FAM83H (P < 0.001), Nu-PANX2 (P < 0.001), and Cy-PANX2 (P < 0.001) (Table 3). Here, PANX2 is linked to metastatic malignant neoplasm in the lymph nodes.