To further evaluate the prognostic value of CXCL13/CXCR5 axis in ccRCC, ccRCC patients in TCGA database were divided into high CXCL13 high CXCR5 expression group (CXCL13+CXCR5+) (n = 178), low CXCL13 low CXCLR5 expression group (CXCL13−CXCR5−) (n = 177) and high CXCL13 low CXCR5 or low CXCL13 high CXCR5 group (CXCL13+CXCR5−/CXCL13−CXCR5+) (n = 178) according to the median value of CXCL13 and CXCR5 expression. The gene discussed is CXCR5; the disease is nonpapillary renal cell carcinoma.