Available RNA-Seq data from the PDX lines, used in the previously reported preclinical trial (15), showed that among analyzed HR and BER pathway genes, the expression of BRCA1 was trending lower in all five TMZ/veliparib responsive lines as compared to 10 non-responsive GBM lines that were analyzed (p = 0.10, Figure 1D). Here, BRCA1 is linked to glioblastoma.