Given this background, the aim of the present study is to evaluate the effects of 60-day ALE supplementation on baseline cytokines (IL1, IL6, TNF-alpha, and MCP-1) levels, natural killer (NK) response to a low, medium, and high stimulus, and lipo-metabolic profile, such as HDL-C, LDL-C, total-C/HDL-C ratio, TG, ApoB/ApoA ratio, LAP, glucose, insulin, WC, and HOMA-IR, in adults with low HDL-C and mild hypercholesterolemia. The gene discussed is APOB; the disease is familial hypercholesterolemia.