RUNX2 and osteosarcoma: Among these 114 proteins, thirteen proteins, including CHEK2, TP53, RB1, VEGFA, EGFR, RUNX2, MDM2, MMP2, MET, DHFR, TNFRSF11A, JUN, and RFC1, were reported to participate in the pathological process of osteosarcoma directly.