TARDBP and amyotrophic lateral sclerosis: The development of TDP-43 animal models has offered the opportunity to explore synaptic alterations in ALS (Feiguin et al., 2009; Armstrong and Drapeau, 2013; Handley et al., 2017) and continuous efforts are being made to identify compounds that can facilitate synaptic transmission in ALS (Patten et al., 2017).