TARDBP and amyotrophic lateral sclerosis: For instance, TDP43 has been shown to bind to mRNA and regulate the expression of other proteins implicated in ALS and other neurodegenerative diseases such as FUS, Tau, ATXN 2 and progranulin (Polymenidou et al., 2011; Sephton et al., 2011; Tollervey et al., 2011).