Among these genes TAF15, which is mutated in some case of ALS (Couthouis et al., 2011), has been found to be upregulated in several ALS FUS models including human mutant IPSC derived motoneurons (De Santis et al., 2017), FUS knockout and knockin mouse (Kino et al., 2015; Scekic-Zahirovic et al., 2016). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.