Consistent with hemorrhagic disease, negative control animals showed signs of liver damage as evidenced by increased levels of liver enzyme AST (Figure 3D), and several key cytokines such as IL-1β, IL-6, IL-1Ra, MIP-1α, TNFα, IFN-γ, IL-2, and FGF-β (Figure S3). This evidence concerns the gene FGF2 and hemorrhagic disease.