FOXP3 and type 1 diabetes mellitus: Importantly, we could also establish that the increase in FOXP3+ memory Tregs observed with definitions 1 and 2 (Figures 3B,C) was due to an increase in the non-suppressive FOXP3low fraction whereas the FOXP3hi fraction appeared unaltered in children with T1D (Figure 3D and Supplementary Figure 2).