A MelanA-negative cell clone obtained using sgMelanA1 (sgMelanA1-clone4) did not activate HLA-A*02:01/MART-127L26−34-specific CD8+ T cells, while HSV-1 d106S-MelanA infection of this cell clone induced degranulation as evident from the detection of CD107a at the surface of CD8+ T cells (Figure 4A). This evidence concerns the gene SEPTIN4 and infection.