INS and obesity due to melanocortin 4 receptor deficiency: Previous evidence has shown that DRT in rats with diabetes (Talebi-Garakani and Safarzade, 2013), middle-aged (Jung et al., 2015) and obesity induced by a hyperlipidic diet, reduced pro-inflammatory markers, and was associated with improved insulin sensitivity in skeletal muscle (Panveloski-Costa et al., 2011).