Moreover, compared with the NP-SPION/PTX group, Pep-NP-SPION/PTX showed an obvious higher distribution no matter whether an external magnetic field was added, which revealed that the modification of Pep-1 peptide could accelerate the accumulation of nanoparticles into the tumor section via IL-13Rα2 mediated endocytosis. The gene discussed is IL13RA2; the disease is neoplasm.