Contrasting evidence has been reported for the −667C variant in the PIN1 promoter, which was found to associate with a low risk of developing nasopharyngeal carcinoma (Li et al., 2013), but a high risk for oral squamous cell carcinoma and HCC (Yao et al., 2014; Huang et al., 2016). The gene discussed is PIN1; the disease is hepatocellular carcinoma.