Moreover, the BIS-MEP treatment suppressed more than 50% of Aβ deposition, inhibited astrocyte and microglia activation, and decreased the release of TNF-α and IL-6 in the hippocampus, which blocked neuroinflammation and neuronal death, and more importantly, reversed the cognitive and memory deficits in the AD mouse model in the Morris water maze test. Here, IL6 is linked to Alzheimer disease.