We finally obtained 16 hub genes associated the staging of bladder cancer, including CDH11, COL3A1, COL6A3, COL5A1, AEBP1, COL1A2, NTM, COL11A1, THBS2, COL8A1, COL1A1, BGN, MMP2, PXDN, THY1, and TGFB1I1. The gene discussed is PXDN; the disease is urinary bladder cancer.