After the weighted gene co-expression network analysis of bladder cancer and the examination of the hub genes, we find THY1, AEBP1, CDH11, COL1A1, COL1A2, COL11A1, MMP2, PXDN, BGN, COL5A1, COL8A1 associated with the tumor stage as well as tumor patients’ prognosis. The gene discussed is COL5A1; the disease is urinary bladder carcinoma.