We finally obtained 16 hub genes associated the staging of bladder cancer, including CDH11, COL3A1, COL6A3, COL5A1, AEBP1, COL1A2, NTM, COL11A1, THBS2, COL8A1, COL1A1, BGN, MMP2, PXDN, THY1, and TGFB1I1. This evidence concerns the gene AEBP1 and urinary bladder cancer.