We finally obtained 16 hub genes associated the staging of bladder cancer, including CDH11, COL3A1, COL6A3, COL5A1, AEBP1, COL1A2, NTM, COL11A1, THBS2, COL8A1, COL1A1, BGN, MMP2, PXDN, THY1, and TGFB1I1. Here, THBS2 is linked to urinary bladder cancer.